Cell-cell adhesion is a fundamental prerequisite for the development of multicellular architecture and is facilitated by specific adhesion molecules. Cadherins, divided into several subfamilies, [...]
The nuclear envelope consists of a double-layered membrane and separates the nucleoplasm from the cytoplasm of the cell. Numerous proteins are anchored in the inner nuclear membrane, interacting [...]
Delta(4)-dihydroceramide desaturase, the protein encoded by DEGS1, acts as a catalyzing enzyme in the synthesis of ceramide, a basic building block of sphingolipids. Sphingolipids are essential [...]
Mutations of the LZTR1 gene are involved in the development of tumors and both, autosomal dominant and autosomal recessive variants have been described to cause Noonan syndrome. Yet, how exactly [...]
DNA methylation is an essential epigenetic mechanism in the regulation of gene expression. Specific enzymes, DNA methyltransferases, add methyl groups to certain nucleotides of the DNA and may [...]
DNA-dependent RNA polymerases catalyze the synthesis of different types of RNA during transcription in eukaryotic cells. The protein encoded by POLR3A forms the largest subunit of the RNA [...]
MSL (male specific lethal) factors commonly act in a protein complex to regulate chromatin-associated gene transcription. MSL3, one of these factors, is responsible for incorporation of MOF, a [...]
Skeletal dysplasias are a large group of disorders characterized by specific anomalies in bone development and associated with features including dislocations of large joints, scoliosis, short [...]
Protein-bound iron-sulphur clusters are important biological cofactors and play a crucial role in electron transfer reactions. Additionally, they fulfill essential functions in diverse cellular [...]
Genetic or functional dependencies are often used by cancer cells to compensate the loss of function of one gene by the function of another gene in order to persist. By using genome-wide analyses [...]
